The latest in a long tradition of bands who've managed to utilise videogames and game controllers to make music has been unearthed by CNET. Behold, the Guitar Zeros, a US band who've modified their Guitar Hero controllers to make, 'synthesised sounds'.
The band's website features a helpful guide on converting your own Guitar Hero axe in a similar fashion. I'm not sure if it's permanent - best check before you give it a go.
Previous examples of this sort of thing include The Electric Family who released a whole album of music created using Mario Paint on the SNES. Then there's Nullsleep, the band name of New York musician, Jeremiah Johnson (who also co-founded 8bitpeoples, a collective of musicians inspired by early console and computer music). Oh and the Mikro Orchestra Project (formerly Gameboyzz Orchestra Project), an experimental art group that uses (abuses?) networked Game Boys.