Michael White looks back on the first day of the Conservative party conference in Manchester as the party faithful guard against complacency. On a day when all eyes are on George Osborne, as he stakes his claim to take charge of Britain's troubled economy, the Guardian's head of business Dan Roberts assesses the task ahead. And Andrew Gimson, author of a biography of Boris Johnson, explains how the London mayor is teasing David Cameron while playing to the gallery.
From climate talks in Bangkok, environment editor John Vidal explains why developing countries - and China - have accused the world's wealthiest nations of "sabotaging" a global warming treaty.
Science correspondent Ian Sample looks at the pioneering study of the ageing process by the three researchers who've won this year's Nobel prize for medicine.
And security editor Richard Norton-Taylor assesses the claims made in the first ever official history of MI5 that three Labour MPs were Soviet agents.
