Spain will be looking to bounce back when they travel to Greece after losing the UEFA Nations League final to France last month and look to qualify for the 2022 World Cup in Qatar.
La Roja are the favourites here at 21/50 with Grosvenor Sport while the Greeks are 17/2 longshots and a draw is 10/3.
Luis Enrique's side have a challenge on their hands in their penultimate qualifying group stage match with the former World and European champions with the side just two points behind Group B leaders Sweden.
The Greeks are in with a slender chance of qualifying to the second round but if they have any hope of progressing they will need to up their game against the visitors unlike their last match against Sweden.
Greece's head coach John van't Schip could only watch on as his side lost to the group leaders 2-0 and go down to 10-men when Pantelis Chatzidiakos received his marching orders at the Friends Arena - think the defender forgot the memo on that front.
Spain may still feel bruised from losing the Nations League final but the prospect of leapfrogging Sweden and winning automatic qualification to Qatar next winter will be enough to motivate the side to focus and put the past behind them.
Tips
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Throughout their whole qualifying campaign, Spain have not blanked in any of their qualifying matches - finding the net 13 times. They are 13/20 to score over 1.5 goals which I think is a good bet to make giving their form in this campaign.
However, in their last five meetings, both sides have managed to find the net in four of them so I am backing for that tradition to stick but with Spain to come back home with all three points ahead of their final qualifier against Sweden.
Team news
The hosts have Pantelis Chatzidiakos and captain Anastasios Bakasetas suspended and will miss the match at the Athens Olympic Stadium.
The uncapped Dimitris Goutas could make his debut with Dinos Mavropanos not involved in the squad.
Spain have forwards Ferran Torres, Ansu Fati, Gerard Moreno, Yeremi Pino and Mikel Oyarzabal all watching the game at home.
In defence, Eric Garcia joins the worrying list of absentees for Enrique so Pau torres and Aymeric Laporte are likely to partner up at the back with Unai Simon starting in goal.
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