Can Tottenham summon the spirit of last season's Champions League and secure the result they need to progress to the quarter-finals?
Spurs were involved in dramatic games in last season's tournament, in both the quarter-finals and semi-finals, with the side coming from a 1-0 home defeat in the semi-final with Ajax to go through on away goals following a stunning Lucas Moura hat-trick.
Lucas is set to lead the line again, with injuries to Son Heung-min, Harry Kane and Steve Bergwijn, but what of the rest of the team?
Jose Mourinho is bereft of options, so we asked our reporters who they would play if they were in charge.
Alasdair Gold - Senior Tottenham writer
As always this season it's about which players are fresh enough to pull on the Tottenham Hotspur shirt.
Steven Bergwijn and Ben Davies did not train on Monday and look to be out of the match in Germany with their injuries.
The players who did not start at Burnley will likely come into the team, including Harry Winks, Giovani Lo Celso, Serge Aurier and Lucas Moura and possible Gedson Fernandes as well.
Out of the rest, Mourinho has to decide who is ready to play another game of football just three days later.
Tanguy Ndombele is unlikely to start again after the head coach criticised his display on Saturday.
The Portuguese must also decide whether to stick with the back three he started at Turf Moor with or go with four at the back as he switched to in the second half.
Gold's team: Lloris; Aurier, Dier, Alderweireld, Vertonghen; Gedson, Winks, Lo Celso; Lucas, Alli, Lamela.
Rob Guest - Tottenham writer
Jose Mourinho is likely to make a couple of changes to his Tottenham team after switching things up at Burnley.
The head coach went very defensive at Turf Moor with five centre-backs on the pitch and he cannot afford to do that against RB Leipzig with a place in the quarter-finals up for grabs.
Spurs need to go with four at the back and that means Serge Aurier coming in to give an attacking option down the right.
Giovani Lo Celso has to start if the Lilywhites have any chance of going through, with Harry Winks, unused at Turf Moor on Saturday, named alongside him in midfield.
Mourinho has very little options to choose from in attack and this means Gedson gets his chance in Steven Bergwijn's absence.
Guest's team: Lloris; Aurier, Alderweireld, Dier, Vertonghen; Winks, Lo Celso; Gedson, Alli, Lamela, Lucas.
Lee Wilmot - Live editor and Tottenham fan
Well, after Steven Bergwijn picked up an injury it really does make choosing an attack rather simple now.
No Bergwijn, no Son Heung-min, no Harry Kane - Lucas Moura up front it is.
Behind him Giovani Lo Celso just has to play, whether he's tired or not. He should be joined by Erik Lamela and Dele Alli.
Then the midfield two should be Harry Winks and Oliver Skipp, with the defence behind them of Serge Aurier, Toby Alderweireld, Eric Dier and Jan Vertonghen.
Wilmot's team: Lloris; Aurier, Alderweireld, Dier, Vertonghen; Skipp, Winks; Lo Celso, Lamela, Alli, Lucas.
Now it's time for you to have your say.
You can pick the team you would play if you were the manager using our interactive gadget below.
Who gets your vote in the back-line, which appears to be the only area up for debate?
Share your teams with us on Twitter (@Spurs_FL) and Facebook (COYSFootball.London).
