Gareth Southgate is risking the wrath of Jose Mourinho as he plans to start Harry Kane against Denmark on Wednesday.
England managed to beat Belgium on Sunday without the services of their captain.
Kane was absent from the starting XI after it emerged that he had suffered an injury scare in training the night before.
However, Southgate insisted he was feeling the effects of muscle fatigue rather than being injured.
Nevertheless, Tottenham requested that the forward return to the club.
England refused and instead Kane came on against Belgium, in a match that was won 2-1 after a Mason Mount effort in the second-half.
Spurs continue to be fearful of their main man aggravating any muscle problems which could become an issue for the club during a busy period of matches.
It comes after a series of barbs between Mourinho and Southgate over Kane's fitness.
Both club and country are reliant on the 27-year-old, while England have one more match before the end of this month's international break.
The Three Lions take on Denmark in a crucial clash for their Nations League qualification after going top following their win over Belgium.
The last time these two countries faced each other it ended 0-0 and Southgate wants as much firepower as possible.
It has led him to decide to give Kane a lengthy run-out against the Danes, report the Daily Mail, risking huge backlash from Mourinho.
Further dialogue is expected between England and Tottenham physios.
But barring a major change of heart, Southgate will not authorise his return to club duties.
Meanwhile, the England boss was full of pride for his side after a win over World's No. 1 country Belgium.
He said: "We’re so young, it is an experience for them to play against such a top team and should give them a sense of what might be possible over the next few years for them.
"Going at 1-1 the game felt a bit calmer than going in a goal behind. I thought the players in the second half, the way they used the ball was tremendous and we defended as a team.
"Every time somebody got beaten there was another man there to tidy up. I am very proud of what they did."
