Tottenham Hotspur have the chance to move within three points of fifth-place West Ham United today as the two rivals meet at the London Stadium.
The Hammers are enjoying a fantastic season and look to be in contention for a Champions League place.
Spurs, meanwhile, have not experienced such a strong campaign and sit down in ninth place, but have the chance to climb up the table at lunchtime.
Jose Mourinho, though, will have to face West Ham without a trio of important players, who are missing through injuries.
Sergio Reguilon, Serge Aurier and Giovani Lo Celso will be missing for the London derby, with Mourinho confirming in his post-match press conference after Spurs' Europa League win against Wolfsberger on Thursday night.
The Spurs boss said this on Lo Celso and then Reguilon: "I don't know. Not close. I think Reguilon next week against Wolfsberger home match.
"Not Gio. No, no, no. Gio is still a few weeks away and of course we need him because he gives us lots of qualities and options and we've missed him for a long time," Mourinho concluded.
Apart from those three injury problems, Mourinho will have a full squad to choose from and with Gareth Bale's strong performance earlier in the week, he could face a selection headache at the top end of the pitch.
Bale scored and got an assist in Thursday night's victory in Europe and could be in contention to make a rare Premier League start.
Full Tottenham squad
Goalkeepers: Hugo Lloris, Joe Hart and Alfie Whiteman.
Defenders: Matt Doherty, Toby Alderweireld, Eric Dier, Davinson Sanchez, Joe Rodon, Japhet Tanganga and Ben Davies.
Midfielders: Harry Winks, Tanguy Ndombele, Pierre-Emile Hojbjerg, Moussa Sissoko and Dele Alli.
Forwards: Heung-min Son, Steven Bergwijn, Lucas Moura, Gareth Bale, Erik Lamela, Harry Kane and Carlos Vinicius.
