Arsenal travel to Manchester United on Sunday for a crucial Premier League clash at Old Trafford.
Both sides were victorious in their midweek European games, with Arsenal beating Dundalk 3-0 whilst United recorded an impressive 5-0 win against RB Leipzig.
But it's back to domestic duty, and both clubs will want to pick up three points to push for the top four places.
United have several injury problems, with up to five players ruled out of the game.
Eric Bailly has been ruled out until after the international break, whilst Jesse Lingard and Phil Jones are long-term absentees.
Meanwhile, Anthony Martial serves the final match of his three-game ban, whilst Alex Telles is self-isolating after testing positive for coronavirus.
Martial's absence could see Edinson Cavani start his first Premier League match for United, but Solskjaer may field Mason Greenwood and Marcus Rashford in a two, with a midfield diamond behind.
Speaking ahead of the game, Solskjaer admitted his side would have to show their best to get the better of Arsenal.
"Arsenal is always gonna be difficult, because they are a very good team with a good manager who has got some great ideas on how football should be played and I’m looking forward to it," he said.
"Surprised it’s 100 games [managed for Manchester United], it’s gone really quickly even though a lot has happened, so let’s hope I can celebrate No.100 with a good performance and a good result. I’ve enjoyed it so far."
Solskjaer added: "At the moment, we are looking like a Man United squad, I’ve got opportunities, competition for places, and any successful team in the modern era of football have had the option to rest players, to rotate and that is probably the only way you can last in this most intense league in the world and also with the Champions League involved, you want to go for the trophies."
Full Manchester United available to face Arsenal:
Goalkeepers: David De Gea, Dean Henderson.
Defenders: Aaron Wan-Bissaka, Timothy Fosu-Mensah, Victor Lindelof, Harry Maguire, Axel Tuanzebe, Luke Shaw, Brandon Williams, Marcos Rojo.
Midfielders: Donny van de Beek, Nemanja Matic, Scott McTominay, Fred, Paul Pogba, Juan Mata, Bruno Fernandes, Daniel James.
Strikers: Edinson Cavani, Marcus Rashford, Mason Greenwood, Odion Ighalo.
