Liverpool captain Jordan Henderson will miss the trip to Fulham with an ankle injury sustained in the midweek Champions League victory over Bayern Munich.
It means Fabinho will come back into the side, having initially been rested for the Champions League tie.
"With Hendo we know now it's serious enough to rule him out for the weekend," said Jurgen Klopp. "The international break will be long enough to bring him back," Klopp told a news conference.
"It was a little one with the ankle. It was the best scan we could get but still not good enough. Not good but OK."
Fellow midfielder Naby Keita will be assessed after missing the trip to Germany with a minor injury.
Meanwhile, Fulham caretaker boss Scott Parker has no new injury concerns.
The Whites, struggling in the relegation zone, will still be without a trio of players - although Andre Schurrle is training again after a virus.
Defender Alfie Mawson (knee) remains absent as does goalkeeper Marcus Bettinelli after surgery on his own knee issue.
Fulham vs Liverpool predicted XIs
Fulham XI: Rico, Odoi, Nordtveit, Ream, Bryan, Chambers, McDonald, Cairney, Babel, Mitrovic, Sessegnon
Liverpool XI: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Wijnaldum, Fabinho, Lallana, Mane, Salah, Firmino
