Tottenham sealed a last-gasp 2-1 win over Fulham at Craven Cottage as goals from Dele Alli and Harry Winks completed a turnaround after Fernando Llorente's own goal.
Llorente scored a first-half own goal and then missed a glorious late chance to win the game after Dele Alli had headed Spurs level, before Alli himself limped off with a hamstring injury.
However, Spurs were rewarded on their last attack of the game as Georges-Kevin N'Koudou - on for Alli - crossed for Winks to head home from close range in the 93rd minute.
Fulham boss Claudio Ranieri threw new signing Ryan Babel, signed on a six-month loan from Besiktas this week, into the line-up in place of Ryan Sessegnon.
Mauricio Pochettino gave Llorente the chance to lead the line from the start in Kane's absence, but things could hardly have gotten off to a poorer start for the Spaniard.
With just over a quarter of an hour played, Llorente was caught on his heels as Jean Michael Seri's corner ricocheted off his shin and past Lloris to give the home side the lead.
He would have had chance to make immediate amends has Erik Lamela's square pass not been woefully over-hit, but it was Fulham who came closest to adding to the score before the break.
Aleksandr Mitrovic thought he'd doubled the lead, heading the rebound home after Lloris had pushed away André Schurrle's terrific volley, only to see the flag correctly raised, before Jan Vertonghen made a vital last-ditch challenge on Babel.
Fulham were made to pay for not increasing their lead during their spell of good pressure shortly after the restart, when Alli headed Christian Eriksen's back post cross past Rico after awful defensive work from Tim Ream and Denis Odoi.
A deflection of Odoi sent Danny Rose's strike crashing off the crossbar, before a game-long battle between Mitrovic and Davinson Sanchez threatened to take centre-stage, with both carded for some handbags.
It wasn't until eight minutes from time that Spurs fashioned a clear chance to win it, but it was not to be for Llorente, who managed to get only the faintest of touches on Rose's cross when he looked certain to score.
Dele Alli's injury threatened to cap a nightmare day for Pochettino, but Winks' header in the 93rd minute - off a cross from Alli's replacement, Georges-Kevin N'Koudou - meant Spurs had the last laugh at the Cottage to boost their top four hopes.
