Perth and Kinross will move beyond level zero on Monday, confirmed the first minister.
It means from August 9 many of the coronavirus lockdown restrictions active since March 2020 will be removed.
Physical distancing requirements and rules on smaller event gatherings of will be axed as Scotland enjoys so-called 'Freedom Day' from next week.
The law requiring residents to maintain physical distancing when visiting shops or hospitality venues will be scrapped.
It also means nightclubs, live music venues and theatres can finally reopen their doors after being forced to remain closed for 18 months.
Capacity limits of 2000 people indoors and 5000 people outdoors for events will remain in place, although some exceptions may be possible on a case-by-case basis.
Customers will still be expected to register their details when visiting entertainment venues as the Test and Protect service will continue to operate to monitor future outbreaks of COVID.
Self-isolation rules in Scotland will also be reduced drastically from August 9.
From that date an adult who is identified as a close contact of someone who has tested positive for COVID will no longer be required automatically to self-isolate for 10 days.
If someone is double-vaccinated - with at least two weeks having passed since the second dose – and if they have no symptoms, they should get a PCR test as soon as possible. If the PCR test is negative, self-isolation can then be ended.
Nicola Sturgeon added that face coverings will be mandated in law "for some time to come".
School pupils will continue to use facemasks in schools for the new term and social distancing will remain in classrooms for six weeks after children return in August.
In her COVID update in the Scottish Parliament earlier today (August 3) the first minister credited the "continued success" of the vaccination programme.
But did warn that the move out of level zero "does not signal the end of the pandemic".
She told MSPs on Tuesday: "This change is significant and hard-earned.
"The sacrifices everyone has made over the past year-and-a-half can never be overstated.
"However, while this move will restore a substantial degree of normality, it is important to be clear that it does not signal the end of the pandemic or a return to life exactly as we knew it before COVID struck.
"Declaring freedom from, or victory over, this virus is premature.
"The harm the virus can do, including through the impact of long COVID, should not be underestimated.
"And its ability to mutate may yet pose us real challenges.
"So even as we make this move today, care and caution will still be required, and that is why I want to focus now on the protections and guidance that will remain in place after August 9."
Further information can be found on the Scottish Government website.
