Four people were taken to hospital with "serious injuries" following a night time collision in Aberystwyth .
Traffic reports showed the A487 was closed from around 10pm on Saturday, November 16 to 7.45am on Sunday, November 17.
The road was closed in both directions with the stretch between the A4159 and the B4572 affected.
Writing on Twitter, the roads policing unit described the collision as "serious".
A spokesman for the Welsh Ambulance Service confirmed they were called to the incident at 10.20pm on Saturday. He said the incident happened on the A487 in Comins Coch, Aberystwyth.
The spokesman said four people suffered "serious injuries" and were taken to Bronglais Hospital.
What to do if you're in a collision or have witnessed one:
Five ambulances and a rapid response vehicle attended the scene.
He confirmed there was a further call at 2.54am on Sunday requesting "air transport" for a patient from Bronglais Hospital.
He said he could not confirm whether the patient had been involved in the collision.
Penarth Coastguard said they were called to set up the helicopter landing site at Blackweir in Cardiff at 3.50am.
A spokesman said: "While returning from our previous call, we were tasked to set up HLS Blackweir for rescue inbound from Aberystwyth."
He said they received a male casualty with head and back trauma. The man was taken to the University Hospital of Wales in Cardiff.
Dyfed-Powys Police said it was "not able to release any more information" at this time.
