Two men were seriously injured after a car they were in crashed near to a tram stop following a police pursuit.
Greater Manchester Police confirmed four men were taken to hospital in total.
The driver and a third passenger were said to have suffered minor injuries, police said.
According to reports, the car was travelling at speed at the time of the collision near to the tram stop in Audenshaw, Tameside, at around 11.35pm on Wednesday night.
The A635 Manchester Road in Audenshaw was closed in both directions between Snipe Way and the A662 Droylsden Road as emergency services attended the scene.
It's understood those involved were cut out of the wreckage by firefighters and taken to hospital.
Droylsden Road was also closed at the Audenshaw Metrolink stop on Manchester Road and all trams were halted between the Velopark and Ashton-under-Lyne.
The roads were finally reopened at around 5am on Thursday morning.
Greater Manchester Police confirmed a 'police pursuit ensued' after officers began to follow a car close to Manchester city centre.
The car involved hasn't been described.
It is said to have 'lost control' and collided with street furniture near to the tram stop.
One witness said they believed the car 'flipped' on the tram tracks and rolled over several times, although no further information has been released by police.
Another witness reported the car 'speeding past us' on Droylsden Road with three police cars in pursuit.
Greater Manchester Fire and Rescue Service was in attendance and the police helicopter was circling above in the aftermath of the collision.
No ages for the injured parties have been revealed.
A force spokesman said two of those taken to hospital - both passengers - had 'serious injuries', but there was no further information.
Police said enquiries were continuing.
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