Four people are dead and a fifth has been hospitalised after a single-vehicle rollover on the Kakadu Highway, south of Darwin.
Northern Territory Police were alerted to the incident around 8:15am on Friday, and believed the crash occurred around 80 kilometres from Pine Creek overnight.
Two men and a woman died at the scene, and another woman died on the way to hospital.
A 49-year-old woman is being treated in hospital.
"Speed and alcohol were definitely factors and [the car] has rolled multiple times," Commander Tony Fuller said.
"[The driver and passengers] were last seen about 8:30pm last night at the Mary River Homestead in a silver Nissan X-Trail, so we're appealing for anyone on the highway last night to contact police."
Commander Fuller said police were alerted to the incident after a group of tourists came across an Aboriginal woman walking along the highway, who was later confirmed to be a passenger of the vehicle and was taken to hospital.
He said it had been a "horrible day" for first responders.
"That takes our road toll up to 42 for the year compared to 23 last year," he said.
"So it's a really horrific road toll this year."
The deceased are yet to be formally identified.
Major Crash Investigators will prepare a report for the coroner.
