Matt Hancock has said people shouldn't travel to Lancashire to watch the Merseyside Derby this weekend.
The Health Secretary said that residents of the Liverpool City Region shouldn't go to pubs in Lancashire to watch the match on Saturday.
Pubs and bars closed in Liverpool on Wednesday after the region was placed under Tier 3 regulations to help stop the spread of coronavirus.
This had led to fears that people in the region will just travel to pubs in the surrounding areas instead.
Labour MP for West Lancashire Rosie Cooper raised the issue in parliament this afternoon.
She asked Mr Hancock: "What action can be taken to protect my West Lancashire constituents who, via social media, have been alerted to the fact that supporters who want to watch the Liverpool vs Everton match this Saturday intend to travel from nearby Tier 3 areas into pubs in West Lancashire?
"This could be a super-spreading event leading to a public health disaster."
Mr Hancock replied: "The principle behind the levels is that if you are resident in an area that is in a very high local Covid alert level then that level applies to you wherever you are.
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"If you live in a lower alert level and you travel to a higher alert level area then the rules of the higher level apply if that is where you are.
"So people who live in the Liverpool City Region should not be travelling to West Lancs because the pubs are open there - that contravenes the regulations and I look forward to working with (Ms Cooper) to try to ensure that that doesn't happen."