Anyone heading to East Midlands Airport with Flybe flights booked have been told not to travel to the airport.
The airline fell into administration this morning after the company ceased trading.
Government officials have said that it is believed that the coronavirus outbreak tipped the airline over the edge.
There were concerns in January after it was suggested that the Government might bail the company out.
A spokesman for the Leicestershire airport said today: "We regret to inform passengers that, as of Thursday 5th March 2020, Flybe has ceased trading. All Flybe flights have been cancelled. Anyone who is booked onto a Flybe flight, and hasn't started their journey, should not travel to the airport.
"The East Midlands to Jersey/Guernsey service, which was operated by Blue Islands under a franchise agreement with Flybe, will continue to operate as normal and passengers will be unaffected. Customers with bookings for Blue Islands operated flights today (Thursday 5 March 2020) should check-in at the airport as normal.
"This is a difficult time for passengers whose travel plans have been disrupted. We will continue to provide information and assistance to anyone who has been affected.
"Passengers who were due to travel with Flybe back to EMA should contact their travel insurance company in the first instance.
"We regret the loss of Flybe which has played an important role connecting communities around the UK. From East Midlands Airport, the airline flew to Belfast and Amsterdam."
A post on Flybe's website states that customers who require further information or assistance should contact the administrators, EY, on 0207 951 7801 or by email at flybeadministration@uk.ey.com .
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