Firefighters were called to a flat in New Islington after a blaze started in a bathroom.
Crews were called to Woodward Street just after 7pm on Wednesday evening.
The blaze appeared to have started in a flat in Woodward Court which is council-run homeless acommodation.
A spokesperson for the Greater Manchester Fire and Rescue Service said it started in the bathroom of a third floor flat.
Nobody is believed to have been injured in the blaze.
The fire has now been extinguished and firefighters have left the scene.
In a statement, the GMFRS spokesperson said: "We were called at 7.07pm today to Woodward Street.
"Five fire engines attended as well as a turntable ladder.
"The fire started in a flat on the third floor and appeared to have started in the bathroom.
"We have now left the scene."
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