A vile troll posing as left a cruel comment on a picture of the missing girl's parents at a restaurant in Scotland.
Kate and Gerry, who was born in Glasgow , were snapped eating out in pictures uploaded to Facebook on Saturday night.
Among the 3,700 comments was an abusive profile set up under the name of their daughte,r who was just three years old when she vanished from a hotel room in the Algarve region of Portugal in 2007.
Her parents, from Rothley in Leicestershire, were dining with friends in a restaurant at the time.
The callous comment read: "Mum and dad are closer than I thought".
It is unclear if the account was set up in Scotland.
A deep dive into the profile revealed a catalogue of horrific racist and homophobic posts, including multiple depraved jokes about the 9/11 terrorist attacks in New York.
Other sick comments joke about being in a relationship with paedophile Jimmy Saville, David Bowie's death and suicide.
While some social media laughed at the repulsive posts, others called it out, branding the online monster "absolutely disgusting" and "bloody sick".
Another wrote: "The poor girl could be dead and you’re sat here making up stupid accounts you horrible person."
While another posted: "I'm shocked at the amount of sick minded people. A 3-year-old has been missing for 12 years, I dread to think what she's been through if she's still alive."
The revolting profile was discovered on a viral post showing Kate, and Gerry, both 51, enjoying a meal while in Scotland.
Pictures show the pair carrying plates of food back to their table believed to be at the Beijing Banquet in Renfrew.
The post has racked up 1,300 likes and has been shared over 3,200 times since being uploaded on Saturday evening.
Sadly, this is not the first time a twisted online account has been set up in Madeleine's name.
Earlier this year the Record exposed a fake Tinder dating account claiming to be 'Maddie', aged 18.
The distasteful profile, with the bio "just want some loving, I have daddy issues, here for a good yin", came up in searches on the app for people seeking dates in Glasgow .
It comes after Netflix released an eight-part documentary series on the infamous case in March this year, featuring theories behind the toddler's disappearance and interviews with multiple key players from the investigation.
Madeleine disappeared from a holiday apartment where she was sleeping with her two younger siblings in Praia da Luz in May 2007.
Kate and Gerry were dining with friends at a nearby tapas restaurant when she vanished from her bed. They did not approve of the documentary and chose not take part.
Social media had been rife with trolling of the parents and nasty comments referencing Madeleine's disappearance when it was aired.
Last month Kate and Gerry thanked the public for 'being by our side' after being granted a £300,000 fund to continue their search.
The couple vowed to continue the worldwide hunt 'for as long as it takes'.
