Manchester City will continue their FA Cup defence against Fulham after being paired with the Cottagers in the fourth round draw.
Pep Guardiola's side cruised into the last 32 after putting Port Vale to the sword at the Etihad on Saturday.
Liverpool's reward for beating Everton in the Merseyside derby is a trip to Bristol City or Shrewsbury.
Tottenham will travel to Southampton, but Jose Mourinho's men must overcome a replay against Middlesbrough first.
So too do Manchester United vs Wolves, with the winners handed a trip to Premier League rivals Watford.
Elsewhere, Chelsea are on the road as they take on former finalists Hull City.
Arsenal take on Leeds United in the final tie of the third round on Monday evening, with the winners travelling to Bournemouth.
Brendan Rodgers' high-flying Leicester side face a tricky trip to Championship promotion hopefuls Brentford.
Sixteen Premier League sides featured in the draw after Brighton, Crystal Palace, Aston Villa and Everton were dumped out over the weekend.
FA Cup fourth round draw in full
- Watford or Tranmere vs Wolves or Man Utd
- Hull City vs Chelsea
- Southampton vs Middlesbrough or Tottenham
- QPR vs Sheffield Wednesday
- Bournemouth vs Arsenal or Leeds
- Northampton vs Derby
- Brentford vs Leicester
- Millwall vs Sheffield United
- Reading or Blackpool vs Cardiff or Carlisle
- West Ham vs West Brom
- Burnley vs Norwich
- Bristol Rovers or Coventry vs Birmingham City
- Man City vs Fulham
- Rochdale or Newcastle vs Oxford
- Portsmouth vs Barnsley
- Bristol City or Shrewsbury vs Liverpool
Ties to be played the weekend of January 25.
