Everton and Liverpool will kick-start their FA Cup campaigns this weekend, facing Hull City and Shrewsbury Town respectively.
The Merseyside rivals have strangely faced off against each other at this stage of the the competition in both the 2017/18 and 2019/20 season, with Jurgen Klopp's side coming out on top on both occasions at Anfield.
It has been a fair few years since either side have won this prestigious cup competition, but could this be the season the trophy is claimed by a Merseyside club?
Everton are first in action on Saturday afternoon against their Championship opponents, meanwhile the Reds are expected to take on League One Shrewsbury at Anfield on Sunday.
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Liverpool shut down their training ground complex earlier this week due to a Coronavirus outbreak, leading to the postponement of their Carabao Cup semi-final first-leg fixture with Arsenal.
But the FA have made clear that matches must continue to go ahead as planned, despite squads up and down the country being decimated by the Omicron variant.
Below are the key details ahead of the third-round ties.
Will VAR be in use?
The controversial technology system will only be used in nine grounds out of a possible 32 at the third-round stage.
Only matches played at the home of Premier League sides will be able to refer to VAR as the FA Cup is not licensed to use it across all its fixtures.
Everton's match at the MKM Stadium will therefore have to rely on the in-game decision-making of referee Andrew Madley on the day. Liverpool, meanwhile, will be able to refer to video footage if required.
Last season VAR was only available only at top-flight stadiums up to the quarter-finals, where all matches were then licensed at Wembley for the semi-finals and final.
It is understood that the FA are yet to decide whether to license later rounds for the current campaign.
What will happen if matches are tied at full-time?
There will be no replays in the third and fourth round of this season's competition.
But they will return up to and including the fourth round of the FA Cup from the 2022/23 season onwards.
Outcomes will be decided on the day of the match, meaning matches will go to extra time and penalties if required.