It could be a case of 11 changes for Tottenham Hotspur as they take on Southampton in the Premier League on Saturday.
Mauricio Pochettino's men will be looking to back on track after the last three results have brought a disappointing draw at Olympiacos, a defeat at Leicester City and then a shock Carabao Cup exit at the hands of League Two side Colchester United.
The Spurs boss could well change the entire team that faced Colchester on Tuesday night with many of his key men rested for the League Cup clash.
Hugo Lloris will return after his time spent with his newborn son with Paulo Gazzaniga expected to be back on the bench.
Pochettino must make a couple of decisions when it comes to his midfield. Does he retain the three man axis in the centre of Harry Winks, Tanguy Ndombele and Moussa Sissoko, fresh from signing his new contract, which is three years plus an option for another?
If he does then that limits the options he can use in the attacking midfield areas, with Son Heung-min, Christian Eriksen, Erik Lamela, Lucas Moura and Dele Alli all then competing for the two spots behind or either side of Harry Kane.
Whatever team is chosen there is going to be someone key left on the bench. Eriksen has been out of form but would Pochettino drop him for three straight matches? Then there's also a big Champions League match against Bayern Munich just a few days later.
Here's how we reckon Spurs will line up at the Tottenham Hotspur Stadium:
(4-3-3) Lloris; Aurier, Alderweireld, Vertonghen, Rose; Sissoko, Winks, Ndombele; Lamela, Kane, Son.