Longeveron Inc (NASDAQ:LGVN) announced the publication of Phase 1 trial results of Lomecel-B on patients with mild Alzheimer's disease (AD) in the Alzheimer's & Dementia journal.
The 33-subject trial met its primary endpoint, demonstrating that Lomecel-B was well tolerated.
Data supported further exploration of Lomecel-B, particularly the therapeutic potential to slow cognitive decline and improve quality of life in patients with AD.
Read Next: Exclusive: Longeveron Kickstarts Its Mid-Stage Alzheimer's Disease Trial.
What Happened: Patients receiving Lomecel-B were not reported to develop a serious side-effect called amyloid-related imaging abnormalities (ARIA).
The Mini-Mental State Exam (MMSE), used to evaluate cognitive status, showed a slower decline in the low-dose Lomecel-B group versus the placebo group.
The Quality of Life score showed a significantly higher (better) score in the low-dose Lomecel-B group versus the placebo group at six months after the single treatment.
A high-dose Lomecel-B infusion showed an increase in left hippocampus volume three months after versus placebo.
The hippocampus is a brain region critical for memory formation.
Next Steps: Lomecel-B is being tested in a new larger Phase 2 study, which commenced in December 2021, and has already treated the first patient.
The new trial is designed to evaluate single versus multiple doses of Lomecel-B for mild Alzheimer's Disease.
Price Action: LGVN shares closed 3.42% higher at $6.95 during after-hours trading on Wednesday.
