Two Nasa astronauts will make the first splashdown return in 45 years.
SpaceX's astronaut carrier the Crew Dragon successfully undocked from the International Space Station (ISS) and has begun its journey back to Earth.
But Robert Behnken and Douglas Hurley are returning to Earth amid the threat of Hurricane Isaias, which is edging closer to their landing destination on the south Florida coast.
Their departure from the ISS was announced by SpaceX, which tweeted: "Separation confirmed. Dragon performing four departure burns to move away from the Space Station.
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Nasa then advised the Crew Dragon was "on a safe trajectory" back to Earth.
What time will people in the UK see the splashdown?
The Crew Dragon is expected to land at around 7.48pm UK time and 2.48pm Florida time.
How to watch the splashdown?
You can watch a live stream of events here.
The astronauts made history on May 30 when they became the first people to launch into low-Earth orbit on a commercial spacecraft that was built by SpaceX.
Their mission, named Demo-2, also marked the first time Nasa launched astronauts from US soil in nine years.
The last time astronauts made an ocean landing was on July 1975 during an Apollo mission.
Since then, spacemen have always landed on terra firma, using Nasa's Space Shuttle or the Russian space agency's Soyuz capsules.
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If all goes to plan, the splashdown will usher in a new era for Nasa, which will have at least one commercial spacecraft ready to launch astronauts into space from US soil.
On entering the Earth's atmosphere, the Crew Dragon will face scorching temperatures of around 1,900C as it deploys parachutes to slow its speed down to around 119 miles per hour, before landing on the ocean.
The splashdown is the final step in the mission designed to test SpaceX's human spaceflight system - including launch, docking, splashdown, and recovery operations.
