The Europa League heavyweights can put themselves in pole position to progress to the knockout stages tonight.
The fourth round of games is upon us and there's plenty to watch with action everywhere from Scotland to Kazakhstan.
Plenty of Irish fans will be interested to see how Manchester United and Wolves get on as the pair host Partizan Belgrade and Slovan Bratislava.
Here's four tips that could make you a fortune tonight:
Celtic +2 handicap vs Lazio - 4/9
Celtic took three points from the reverse fixture two weeks ago, and they're capable of having another crack at the same.
But Lazio need points and are likely to have targeted this with to get just that, you'd expect them to dominate.
Celtic could nick a draw, but a +2 handicap gives that buffer in case that isn't the case.
Man United to lead at half-time and full-time vs Partizan - 21/20
Ole and United can take a big step towards the knockout stages tonight at Old Trafford.
The kids got out of Belgrade with three points the last day, and nothing less than that is expected tonight in Manchester.
They'll look to rack up some goals tonight, and the earlier that comes - the more they may score. United to control it from early on is a decent price.
Besiktas win vs Braga - 11/2
On first look, this is a real longshot - but here us out.
Besiktas endured a horror start to the season both in Europe and in Turkey, but they've turned a real corner domestically that is bound to reflect somewhat in Europe.
Even though their chances of progressing are up in smoke - a team of the calibre of Besiktas with nothing to play for often tends to make things interesting by producing a spiteful performance of sorts to disturb things up top.
11/2 is worth a punt.
Wolves to win to nil vs Slovan Bratislava - 11/10
This one is pretty clean cut, Wolves got the win on the road the last day - and they should do the same on their own patch.
In fact, they should have way too much for Slovan Bratislava and Nuno Esperito will be hoping his side can also keep a clean sheet.
The Wolves win seems written in the stars, and 11/10 is a healthy price for them to have no blips along the way.
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