The European Championships and the coveted Henri Delaunay Trophy have evaded England and all of Gareth Southgate's predecessors.
Portugal won their first major competition last time out at Euro 2016 after Eder's extra-time winner against hosts France.
Eleven cities will host 51 games after it was announced in 2012 that it will be held across Europe after the competition surpassed the landmark 60 years in 2018.
The pandemic forced UEFA to take the decision to postpone the tournament in March 2020, but 15 months on, Euro 2020 will begin this weekend.
Wembley will host all three of England 's group stage matches, two round of 16 matches, the semi-final and the final on July 11.
Scotland are among the home nations looking to progress through the tournament as they appear in their first major tournament since 1998, whereas Wales will be hoping to replicate five years ago after their run to the semi-final.
England will need to see off the challenge of Croatia, Scotland and the Czech Republic to enter the knockout stages.
The top two from all Groups A-F will all enter the knockout stages at the round of 16 stage, similarly to championships in France, four of the third-placed teams in those groups will be given a second chance in the competition as the best-third placed team.
This year's competition has welcomed an increase to the prize money compared to 2016.
Portugal received €8m (£6.8m) for their triumph in Paris, however, the victor at the end of this summer's tournament will receive an extra €2m taking the total up to €10m (£8.6m).
Full breakdown of competition financial rewards
Qualification: €9.25m (£7.9m) each team
Group Stage: €1m per win (£850k), €750k per draw (£600k).
Round of 16: €1.5m (£1.2m) awarded to every team in last 16 round.
Quarter-Finals: €2.5m (£2.1m) for every team in the last eight.
Semi-Finals: €5m (£4.2m) for every team in the last four.
Runners-up: €7m (£5.9m).
Champions: €10m (£8.7m).
Max Potential Earnings: €32m (£27m).
England are amongst the favourites to win the competition and if they were to go all the way not only would they pocket up to £27m but also win the elusive piece of silverware.
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