Northern Ireland Women will take on England at Wembley in a World Cup Qualifying clash on October 23.
England are top seeds in qualifying Group D.
Senior women’s team boss Kenny Shiels said: “This is an amazing piece of news for the team and my staff and I am excited to take our country to play at the home of football.
"But rest assured we will go to London and be competitive.”
Wembley has only ever hosted two England women's football matches with both games against Germany.
It was match in November 2019 that the Lionesses played in front of a record crowd for a home fixture of 77,768.
Irish FA chief executive Patrick Nelson added: “We all recognise Wembley as a world class venue and this is a great opportunity for Kenny’s team to continue in what we hope will be a successful World Cup qualification campaign.”
The two countries last met at St George's Park in a friendly back in February which England won 6-0.
Northern Ireland will start their FIFA Women’s World Cup 2023 qualification campaign with two home games against Luxembourg on 17 September and Latvia on 21 September.
Tickets for the England v Northern Ireland game are due to go on general sale on 5 August.
