Gareth Southgate's England are looking to make it two wins from their opening two European Championship matches for the first time in the nation's history as Scotland visit Wembley.
Captained by Liverpool stalwart Andy Robertson, the Scots will be hoping to dent the Three Lions' aspirations of securing a place in the knockout stages as Steve Clarke's men look to pick up their first points of the tournament.
The magnitude of the clash couldn't be bigger as the auld enemy look drag their Euro 2020 fate until the final game against Croatia at Hampden Park next week.
Jordan Pickford looks set to start between the sticks for England as Dominic Calvert-Lewin eyes a starting spot and with Jordan Henderson facing a race against time to be in Southgate's 18-man squad just a day after he turned 31.
The Czech Republic currently lead Group D after their 2-0 win over Steve Clarke's side on Monday, they're due to kick-off prior to the oldest international fixture, either result in that game could add further anticipation and permutations going into the match at the home of English football.
Here is the lowdown:
What time is kick-off?
England v Scotland will kick-off at 8pm UK time on Friday, June 18.
What TV channel is England v Scotland on?
The match will be televised on ITV and STV.
Can you stream the games?
It will be available to stream for free on the ITV hub.
Who is the man in the middle?
Antonio Mateu Lahoz (Spain) will be the referee at Wembley.
He'll be well known to the Manchester City and Chelsea contingent of the squads after he took charge of the Champions League final, last month.
He took charge of England's 7-0 drubbing of Montenegro, two years ago.
As for Scotland, they will have fond memories of him after he was in the middle for their penalty shootout win over Serbia which secured their place in the tournament.
What are the odds?
England to win - 7/25
Draw - 23/5
Scotland to win- 11/1
Odds provided by Grosvenor Casinos.
