Police are calling for dashcam footage of a crash at Port Stephens on Tuesday.
The collision involving a truck and three cars on Nelson Bay Road near the Fullerton Cove Road intersection ground traffic to a standstill as emergency services rushed to the scene about 3pm.
Initial details indicated at least two people were trapped in their vehicles, as paramedics saw multiple patients at the scene.
A spokesperson for NSW Ambulance confirmed four people had been assessed and two were hospitalised.
Police later confirmed paramedics treated the 44-year-old female driver of a car at the scene before she was taken to John Hunter Hospital in a stable condition.
The 33-year-old male truck driver was not seriously injured.
At least 10 firefighters worked to free those trapped, as police guided traffic through diversions around the scene obstructing both lanes.
Passengers travelling to Newcastle Airport were advised to check NSW Live Traffic and seek advice from their airlines, but airport operations were unaffected.
The road re-opened about 5pm.
Drivers were urged to allow extra time and to travel with caution.
Port Stephens-Hunter police have commenced an investigation into the incident.
As inquiries continue, anyone with information about the crash - or was in the area at the time with any available dashcam/mobile phone footage - are urged to contact Raymond Terrace police station or Crime Stoppers on 1800 333 000.
