David Luiz, N'Golo Kante and Eden Hazard are among those expected to be rested as Chelsea take on Dynamo Kiev in their Europa League second-leg clash on Thursday.
The Blues look set to book their place in the quarter-finals after easing to a 3-0 first-leg win in west London last week.
Ruben Loftus-Cheek and Callum Hudson-Odoi came off the bench that evening, combining for Chelsea's third goal as the latter made it three goals in his last three appearances at Stamford Bridge.
Both could come into Maurizio Sarri's starting XI tonight with Olivier Giroud to lead the line once again.
The France international has six goals in his last six Europa League appearances and with Gonzalo Higuain not making the trip to Kiev due to illness, he will have the opportunity to add to that tally.
Chelsea return to Premier League action away to Everton on Sunday.
Dynamo Kiev vs Chelsea predicted XI
Predicted Chelsea XI: Kepa; Zappacosta, Rudiger, Christensen, Alonso; Barkley, Kovacic, Loftus-Cheek; Willian, Giroud, Hudson-Odoi.
