DETROIT _ Dylan Cease was in trouble. The Tigers loaded the bases with one out in the first inning against the White Sox rookie.
Dawel Lugo hit an easy grounder back to the mound. Cease fielded it cleanly, but his throw to the plate was off the mark. Catcher Welington Castillo recovered the ball in time for the forceout.
Cease got the next batter, John Hicks, to line out softly to third to end the inning without allowing a run, and he wound up going five innings for the victory as the Sox won 5-3 in the first game of a split doubleheader Tuesday in front of 18,455 at Comerica Park.
Cease (2-4) allowed two runs on seven hits, struck out six and walked one on the way to his second big-league victory.
Both of Cease's wins have been against the Tigers. The first came in his major-league debut July 3 at Guaranteed Rate Field.
Jose Abreu and Welington Castillo homered as the Sox improved to 4-1 on the seven-game trip. They have had at least 11 hits in all four victories, including 13 Tuesday.
Abreu had three hits and three RBIs. He capped an 11-pitch at-bat with a solo homer to right in the first.
Ryan Goins tripled and Adam Engel drove him in with a double to make it 2-0 in the second.
The Tigers scored once in the third and fourth to tie the game.
Abreu doubled home Ryan Cordell in the fifth to give the Sox a 3-2 lead. Castillo hit a solo homer to left in the sixth in his first game back from the family medical emergency leave list.
Abreu added an RBI single in the ninth.
Alex Colome allowed one run in the ninth but collected his 22nd save in 23 chances.