Dunelm has reopened a number of its stores across England, including its Cribbs Causeway superstore.
The major homeware retailer operates around 100 stores in England with its other Bristol site at Tramway Retail Park in Brislington, which has not yet reopened.
A spokesperson for the chain said Dunelm has "enlisted the help of experts from the NHS, Government and Trading Standards" to ensure staff and customers are kept safe following the relaunch.
They said: "Over the past few weeks we've gone from normal service to closing our stores and website, to changing the way our warehouse colleagues work, slowly reintroducing online shopping with contact-free deliveries, and most recently we've rolled out contact-free click and collect across all stores.
"During this time we've enlisted the help of experts from the NHS, Government and Trading Standards to advise us of what we needed to do, and what we must continue doing to ensure that we are helping everyone stay safe and well.
"At the start of May, the Government gave their approval for homeware stores to re-open, but we've waited until we feel ready and confident in our safety measures.
"After much planning and preparation, we know we can safely begin to re-open."
The 39 stores reopening will have strict guidelines in place to ensure social distancing and hygiene practices are maintained.
These include a limit on the number of people with a controlled flow of customers around stores, an "enhanced cleaning regime" in all areas and the provision of protective equipment for all colleagues.
The spokesperson added: "As with everything we've done so far we're approaching this carefully, and have initially opened a handful of stores.
"We will continue to listen, adapt and improve how we operate, remaining focused on the safety of our colleagues and customers."
