Drivers face long tail backs on the East Kilbride Expressway after a car struck a lamp post.
Queues have been reported heading from East Kilbride towards Hamilton.
But there are no reports of any injuries police say.
One driver told Lanarkshire Live : "The roads are already busy with the last minute Christmas rush and this has just made it worse. It's horrendous. I just hope everyone is OK."
A police spokeswoman confirmed the incident happened around 12.55pm today.
She told us : "We received a report of a one vehicle road crash on the A725.
"The vehicle left the road and struck a lamp post. We have no reports of any injuries."
And drivers were also faced delays yesterday afternoon after a vehicle hit a barrier on the slip road onto the East Kilbride Expressway from Kingsagte, although no one was injured.
The accident was cleared but traffic was busier than normal.
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