The Dragons welcome French Top 14 high-flyers Lyon on Friday night but they'll be without Wales duo Elliot Dee and Will Rowlands.
Boss Dean Ryan was unwilling to rush hooker Dee back through the return to play protocols after suffering a concussion during the defeat to Perpignan last week.
Rowlands, meanwhile, has got a neck problem and is not fit to make the start line.
In their place, Taylor Davies starts at hooker with Aki Seiuli and Mesake Doge packing down either side of him, and Joe Davies partners Ben Carter at lock.
Captain Harri Keddie, Ollie Griffiths and Taine Basham form a formidable back-row.
Tavis Knoyle partners Sam Davies at half-back, while youngster Aneurin Owen starts at 12, inside Adam Warren. It means the vastly experienced Jamie Roberts will come off the bench.
Jonah Holmes and Rio Dyer pose a potent threat out wide, with Josh Lewis at full-back.
Dragons: Josh Lewis; Jonah Holmes, Adam Warren, Aneurin Owen, Rio Dyer; Sam Davies, Tavis Knoyle; Aki Seiuli, Taylor Davies, Mesake Doge; Joe Davies, Ben Carter; Harri Keddie (c), Ollie Griffiths, Taine Basham.
Replacements : James Benjamin, Josh Reynolds, Leon Brown, Joe Maksymiw, Aaron Wainwright, Dan Babos, Jamie Roberts, Jared Rosser.
Lyon: Clément Laporte; Ethan Dumortier, Alfred Parisien, Thibaut Regard, Davit Niniashvili; Leo Berdeu, Jonathan Pélissié; Vivien Devisme, Yanis Charcosset, Demba Bamba; Killian Geraci, Temo Mayanavanua; Felix Lambey (c), Beka Saginadze, Colby Fainga'a.
Replacements: Mickael Ivaldi, Jérôme Rey, Hamza Kaabèche, Mickael Guillard, Dylan Cretin, Liam Rimet, Charlie Ngatai, Alexandre Tchaptchet.
