Dr Tony Holohan has urged students to take "great care" as the Leaving Cert quickly approaches.
The Chief Medical Officer pleaded with those finishing school to avoid usual end of year gatherings, citing that it's just too risky due to the pandemic.
It comes after education officials warned that those who fall ill with Covid-19 in the coming weeks will not be able to sit the exams, and will be given a calculated grade instead.
The State Exams will run from June 9 to June 29.
Dr Holohan said: "Many of us have fond memories of our time in school, particularly the traditional celebrations that mark the formal end of in-school learning like graduation ceremonies for sixth-year students.
"I am aware that this is an important time in the lives of young adults as they take a break from studying for an evening to celebrate with friends.
“Unfortunately, this year, it is not possible for events of this nature to take place.
"It is very important that all students preparing to sit state exams in June take the necessary precautions now to ensure you do not contract Covid-19, particularly in the last remaining days before the commencement of the Leaving Cert."
He added: "Do not attend graduation ceremonies or events. Take this time to restrict your social contacts and continue to follow the public health advice.”
Dr Holohan was speaking as another 425 cases of Covid-19 were confirmed in Ireland - with a further four deaths being announced.
Of the deaths notified today, one occurred in January, one occurred in February and two occurred in May.
There has been a total of 4,941 Covid-19 related deaths in Ireland.
