Dr Tony Holohan is urging anyone who has not yet received the vaccine to do immediately.
The CMO has shared the latest information regarding Covid-related mortality and said that Covid-19 vaccines are providing very effective protection from severe illness and have fundamentally changed the risk profile of this disease.
In a post online, he adds: "Since the 1st of April, approximately four out of every five people admitted to ICU and approximately three out of every four deaths with Covid-19 were not fully vaccinated."
On Wednesday, the health protection surveillance centre was notified of 1,185 new cases of Covid-19.
292 patients are hospitalised, of which 65 are in ICU.
The most recent figures mean that there has been a total of 5,179 deaths related to Covid-19 notified in Ireland. This includes 24 deaths newly notified in the past week (since last Wednesday).
With the country set to remove more restrictions on October 22, Dr Holohan is urging anyone who has not yet been jabbed to do so immediately.
Dr Holohan added: "It remains vital that those who have not yet received a Covid-19 vaccine do so at the earliest opportunity.
"If you are fully protected through vaccination, then you can have confidence that your vaccination, and your continued adherence to the public health advice appropriate to each environment, is the best way you can protect yourself from Covid-19."
