About 10 million Australians are expected to take a punt on winning a nine-figure pay slip.
Powerball has jackpotted to $100 million, with Thursday's draw 1517 offering the highest lottery prize of the year.
The last time a jackpot of such magnitude was up for grabs, ticket sales peaked at more than 6400 a minute.
Only six people have won $100 million or more in Australian lotteries since 2018 but The Lott's Anna Hobdell says there may be a seventh when the draw closes on Thursday evening.
"From country towns to city streets, we've seen life-changing wins happen to anyone in the most unexpected places," the spokeswoman said.
"The win could happen to anyone, a teacher, a tradie, a retiree, or a parent."
If a single person guesses all eight balls correctly, they'll hold the title as Australia's equal-third biggest lottery winner.
A Queensland woman was the last person to take home $100 million in February 2024, pocketing half of a $200 million Powerball jackpot.
She's moved from Brisbane to the coast and says she's thankful for her dad who picked up the winning call, early in the morning.
"On a day-to-day basis, not a huge amount has changed," she said.
"I still get up for the 6am gym session and the dog still needs to be walked and fed."
An Adelaide man still holds the country's largest pay cheque from a lottery jackpot, after winning $150 million in May 2024.
The odds of a single entry winning the division-one prize are more than 134 million to one.
That's worse than successfully ringing someone by completely guessing their mobile number.
National Gambling Helpline 1800 858 858
