There will not be a 12th Man in Seattle on Sunday, but that won't make the Seahawks a pushover for the Niners in the first of two rivalry games this year.
The 49ers are a team in constant flux because of injuries but have shown resilience and depth that should be the envy of the league. The Seahawks are a team that has perceived stability because they have the best quarterback in the NFL right now.
So what's more important — the quarterback or the 52-man roster surrounding him?
The answer to that question could go a long way to determining who wins Sunday's game between the teams, and where they finish in the NFC West.
Here are five matchups the Niners must win if they want to come out on top Sunday:
