Using a Diablo 4 boss loot table will help you find powerful unique items for your build. Season four, the Season of Loot Reborn, has a new boss to fight in the form of Andariel—an endgame alternative for those who are sick and tired of fighting Duriel and want a change.
Season four also introduces 12 new uniques that drop from Grigoire, Lord Zir, and either Duriel or Andariel. All of these bosses are available in both the Eternal and Seasonal realm, plus there are new Tormented Echoes bosses who cost extra materials to summon, but drop increased loot, plus a Resplendent Spark the first time you kill one of them.
The only caveat is that you will have to get to Nightmare world tier to start gathering materials and fighting bosses, and Torment world tier if you want a crack at Andariel or any of the Tormented Echoes bosses. All that said, here's which uniques you can get from which bosses—including in season four—plus Andariel's loot table.
Diablo 4 Varshan loot table
You can re-fight Varshan from the Season of the Malignant in Nightmare and Torment world tier. If you complete Whispers and defeat Grotesque Debtors to acquire his Malignant body parts, you can summon him below the Tree of Whispers. Here's what he can drop:
Diablo 4 Grigoire loot table
You can fight Grigoire, the Galvanic Saint in Nightmare and Torment world tier if you earn Living Steel through Helltides to summon him. Here's what he drops, including new uniques in season four:
Diablo 4 Lord Zir loot table
You can fight Lord Zir in the Torment world tier if you kill world bosses, complete legion events, or defeat the Helltide's blood maiden to acquire the Exquisite Blood material to summon him. Here's what he drops, including new uniques in season four:
Diablo 4 The Beast in the Ice loot table
You can fight The Beast in the Ice in the Torment world tier if you complete Nightmare Dungeons above tier 30 and gather nine Distilled Fear to create its special Nightmare Dungeon key. Here's what it drops:
Diablo 4 Duriel loot table
You can fight Duriel, King of Maggots in the Torment world tier if you acquire Shards of Agony and Mucus-Slick Eggs by defeating Grigoire and Varshan. Here's what the boss can drop, including uber uniques, plus a new unique in season four:
Diablo 4 Andariel loot table
The new endgame boss in season four is Andariel. To summon her in Torment world tier, you'll need to defeat Lord Zir for Sandscorched Shackles and The Beast in the Ice for Pincushioned Dolls. Since she acts as an alternative boss to Duriel, she has the same loot table including uber uniques:
