Detroit Lions vs. San Francisco 49ers game recap: Everything we know

By Jeff Risdon

The Detroit Lions fell in the 2021 home opener, losing to the San Francisco 49ers 41-33 in Ford Field in Week 1. It’s a setback to start the new Dan Campbell regime, falling to the visiting 49ers and their fast start.

The game turned quite competitive late after the 49ers completely dominated the first two-thirds of the matchup. San Francisco held on with a final defensive stand to thwart a spirited Detroit comeback.

The Lions are 0-1, the 49ers are 1-0.

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