The Detroit Lions head into the second year of coach Matt Patricia’s tenure with a schedule featuring a lot of travel and a couple of nationally televised games.
The Lions open the season on the road in Arizona and return home for a date with the Los Angeles Chargers. An early bye in Week 5 breaks up a rotation where the team alternates between road and home games through Week 8 and a visit from the New York Giants. The Chicago Bears make a return visit for the annual Thanksgiving day game, and the 2018 repeat continues with the Green Bay Packers coming to Ford Field for Week 17.
| Week | Date | Opponent | Time (ET) | |
| 1 | Sun. Sept. 8 | @ | Cardinals | 4:25 p.m. |
| 2 | Sun. Sept. 15 | vs | Chargers | 1 p.m. |
| 3 | Sun. Sept. 22 | @ | Eagles | 1 p.m. |
| 4 | Sun. Sept. 29 | vs | Chiefs | 1 p.m. |
| 5 | BYE | |||
| 6 | Mon. Oct. 14 | @ | Packers | 8:15 p.m. |
| 7 | Sun. Oct. 20 | vs | Vikings | 1 p.m. |
| 8 | Sun. Oct. 27 | vs | Giants | 1 p.m. |
| 9 | Sun. Nov. 3 | @ | Raiders | 4:05 p.m. |
| 10 | Sun. Nov. 10 | @ | Bears | 1 p.m. |
| 11 | Sun. Nov. 17 | vs | Cowboys | 1 p.m. |
| 12 | Sun. Nov. 24 | @ | Redskins | 1 p.m. |
| 13 | Thurs. Nov. 28 | vs | Bears | 12:30 p.m. |
| 14 | Sun. Dec. 8 | @ | Vikings | 1 p.m. |
| 15 | Sun. Dec. 15 | vs | Buccaneers | 1 p.m. |
| 16 | Sun. Dec. 22 | @ | Broncos | TBD |
| 17 | Sun. Dec. 29 | vs | Packers | 1 p.m. |
