Debenhams will axe 2,500 jobs across its stores and warehouses as the chain suffers in the wake of the coronavirus lockdown.
The job cuts will affect roles across the entire Debenhams brand - including within its distribution centres - as the chain plans more store closures.
There is currently no breakdown for store-by-store cuts.
A spokesman for Debenhams said: "We have successfully reopened 124 stores, post-lockdown, and these are currently trading ahead of management expectations.
"At the same time, the trading environment is clearly a long way from returning to normal and we have to ensure our store costs are aligned with realistic expectations.
"Those colleagues affected by redundancy have been informed and we are very grateful to them for their service and commitment to Debenhams.
"Such difficult decisions are being taken by many retailers right now, and we will continue to take all necessary steps to give Debenhams every chance of a viable future."
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The business previously said it would close stores where it was unable to renegotiate lower tenancy fees.
The announcement comes just months after the company revealed it had gone into administration for the second time this year, placing a question mark on more than 22,000 jobs.
The firm has appointed administrators from the FRP Advisory to oversee the process, which has already resulted in the closure of all stores in Ireland.
Debenhams chief executive Stefaan Vansteenkiste said at the time: "In these unprecedented circumstances the appointment of the administrators will protect our business, our employees, and other important stakeholders, so that we are in a position to resume trading from our stores when Government restrictions are lifted.
"We anticipate that our highly supportive owners and lenders will make additional funding available to fund the administration period."
"We are desperately sorry not to be able to keep the Irish business operating but are faced with no alternative option in the current environment," Vansteenkiste said.
"This decision has not been taken lightly and is no way a reflection on our Irish colleagues, whose professionalism and commitment to serving our customers has never been in question."
