Former Ku Klux Klan leader David Duke is running for the Senate seat that will be open in Louisiana.
He made the announcement in a video Friday in which he claimed credit for much of the platform of Republican presidential nominee Donald Trump.
"Thousands of special interest groups stand up for African Americans, Mexican Americans, Jewish Americans, etc., etc.," Duke said. "The fact is that European Americans need at least one man in the United States Senate, one man in the Congress who will defend their rights and heritage."
Duke claimed credit for creating the "America first" agenda advanced by Trump, saying he was "overjoyed" to see the embrace of many of his policy ideas by Republican voters.
"We cannot have free trade without fair trade. We must protect American jobs and businesses," Duke said.
The Louisiana Senate seat is coming open due to the retirement of Sen. David Vitter, who lost a bid for governor.
Duke has come back in the public eye after supporting Trump. He ran for governor in 1991 and lost.