Cyclerion Neurology Candidate Shows Encouraging Action In Preclinical Studies

• Cyclerion Therapeutics Inc's (NASDAQ:CYCN) preclinical studies demonstrated its lead soluble guanylate cyclase (sGC) stimulator, CY6463, improved cellular energetics and reduced inflammation in preclinical models of mitochondrial disease. 
• The data will be presented at the International Conference on cGMP.
• CY6463 significantly increased ATP levels in lymphoblasts derived from patients with mitochondrial complex 1 deficiency (Leber hereditary optic neuropathy or Leigh syndrome).
• CY6463 restored mitochondrial gene expression in lymphoblasts derived from patients with mitochondrial complex 1 deficiency (Leber hereditary optic neuropathy or Leigh syndrome)
• CY6463 significantly decreased the astrocytic marker, GFAP, linked to inflammation in a mouse model of mitochondrial complex 1 deficiency
• The poster also mentioned that healthy, Leigh, and LHON patient cells that do not have a baseline ATP deficit did not increase ATP in response to CY6463.
• Price Action: CYCN shares are up 10.4% at $0.52 during the market session on the last check Friday.