Curtis Jones starts in Liverpool's midfield at Ajax as captain Jordan Henderson drops to the bench.
The Reds get their Champions League campaign up and running in the Johan Cruyff Arena and arrive in Amsterdam without as many as six key players.
Joel Matip and Virgil van Dijk's respective absences sees Fabinho partnering Joe Gomez at the heart of Liverpool's defence as Adrian continues to deputise for Alisson Becker in goal.
Trent Alexander-Arnold and Andy Robertson are the full-backs with Gini Wijnaldum, James Milner and Academy graduate Jones in the middle.
It's a full Champions League debut for the former Under-23 captain as he settles into a patched-up midfield that is without Thiago Alcantara, Alex Oxlade-Chamberlain and Naby Keita while captain Henderson forms part of the substitutes' bench.
The front three retains a familiar look about it as Sadio Mane, Mohamed Salah and Roberto Firmino lead the line against Erik ten Hag's side.
Liverpool: Adrian; Alexander-Arnold, Gomez, Fabinho, Robertson; Milner, Wijnaldum, Jones; Salah, Mane, Firmino.
Subs: Kelleher, Jaros, Henderson, Minamino, Jota, Shaqiri, R. Williams, Cain, N. Williams
