CINCINNATI _ Light rain fell on Great American Ball Park in the bottom of the second inning Thursday, but the Cubs had bigger issues in the fifth inning as the Reds scored three times and earned a 4-2 victory.
The game was stopped because of rain with one out in the top of the sixth. Play resumed after a 1-hour, 51-minute delay.
This marked the first time the Cubs (25-16) lost consecutive games since April 25-26. They were unbeaten in their past 10 series (9-0-1) starting April 8.
After cruising through the first four innings, Jose Quintana allowed a home run to Jose Peralta, threw two wild pitches that allowed the tying run to score, and surrendered a two-out RBI single to Eugenio Suarez that allowed the Reds to erase a 2-0 deficit.
The Reds added a run in the bottom of the seventh on three singles off Tyler Chatwood, who allowed five hits and two walks in two innings.
The Cubs scored twice in the first against Luis Castillo, who had a 1.76 ERA entering Thursday's game. Kris Bryant drew a walk to extend his streak of reaching base safely to 25 consecutive games.
With two out, Javier Baez hit a double down the third-base line that Reds manager David Bell argued was foul.
Nevertheless, the hit put runners in scoring position. Willson Contreras hit a grounder that hit the third-base bag and bounced over third baseman Suarez for a two-run double.
Victor Caratini was activated from the injured list before the game after missing five weeks because of a fractured bone in his left hand. The Cubs optioned catcher Taylor Davis to Triple-A Iowa.
