Big wins for both sides will see these two sides meet up with confidence at a high.
Crystal Palace claim bragging rights after beating Brighton & Hove Albion away from home - picking up four points from their rivals.
While Watford performed a miracle and dominated league leaders Liverpool to a 3-0 demolition, stopping Jurgen Klopp's side from becoming the second Premier League side to finish the season undefeated.
Watford will be hoping this will kickstart their quest for surviving relegation since Nigel Pearson was appointed at the helm.
Their huge win against Liverpool means they are now equal on points with West Ham and Bournemouth - who sit 17th.
With Aston Villa sitting two points behind and with a game-in-hand, the Hornets will be desperate to get a result at Selhurst Park to help maintain Premier League status for next season.
Meanwhile, Crystal Palace pull themselves further and further away from the relegation battle after back-to-back wins including a 1-0 home win against Newcastle United.
Lowdown
Crystal Palace are winless in five matches against Watford in all competitions - drawing twice.
None of the four Premier LEague meetings between Watford and Crystal Palace at Selhurst Park have ended as a draw, with both teams winning two games apiece.
Watford's win against Liverpool ended a run of five games without a win - picking up two out of a possible 15 points.
When and where?
The game will take place at Selhurst Park on Saturday (March 7).
Kick-off time?
The game will kick-off at 3pm
Is it on TV?
No. Due to broadcasting laws, fans in the UK will not be able to watch this match live.
What's your prediction?
Rob Warlow has predicted a 1-1 draw with in his betting preview with thepools.com.
Enter your predictions for free on footie5 for the chance to win £25,000 here.
What are the odds?
Here are the latest odds with thepools.com:
Odds subject to change - Bet responsibly - begambleaware.org - 18+
Team news
James Tomkins, James McCarthy (both thigh) and Jeffrey Schlupp ruled out.
Loan signing Cenk Tosun (knee) has returned to parent club Everton and will require surgery after sustaining an anterior cruciate ligament injury.
Watford's Gerard Deulofeu and Daryl Janmaat (both knee) are ruled out of this weekend's match.
