Crystal Palace will have to face London rivals Tottenham without talisman Wilfried Zaha.
The Eagles have not won a game without the Ivory Coast international, who turns 26 today, since 2016 and have lost every game in which he has been absent since the start of last season.
It places further burden on fellow forward Andros Townsend, who scored their only goal at Chelsea last weekend, with Christian Benteke sidelined until 2019.
For Tottenham, midfielder Victor Wanyama returns from injury to play alongside Harry Winks and Moussa Sissoko in midfield, Juan Foyth makes a second Premier League appearance in place of Davison Sanchez.
The Argentine gave away two penalties on his League debut against Wolves.
Palace are yet to win at home this season and have scored just twice, both from the penalty spot in their last home game against Arsenal, while Spurs have won their last six against the Eagles.
Crystal Palace team to face Tottenham: Hennessey, Wan-Bissaka, Tomkins, Sakho, van Anholt, McAruthur, Kouyate, Miliviojevic, Meyer, Townsend, Ayew
Subs: Guaita, Ward, Kelly, Schlupp, Riedewald, Puncheon, Sorloth
Tottenham team to face Crystal Palace: Lloris, Trippier, Alderweireld, Foyth, Davies, Wanyama, Sissoko, Lamela, Dele, Lucas, Kane.
Subs: Gazzaniga, Aurier, Dier, Winks, Eriksen, Son, Llorente
