Hundreds gathered along Wilmslow Road in Rusholme after Pakistan beat India at the T20 World Cup.
Celebrations have been ongoing since around 7pm with fans flocking to the main road.
In videos shared on social media, crowds of people have congregated along the Curry Mile.
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They can be heard chanting and singing after the historic 10-wicket victory.
At one stage an ambulance got stuck trying to navigate through, one witness reported.
The paramedics phoned for help from the police in an attempt to get through, but eventually the crowd managed to manoeuvre the ambulance through.
Press Association reports that Babar Azam and Mohammad Rizwan sensationally negotiated a potentially tricky chase of 152 as Pakistan claimed a historic first World Cup win over arch rivals India at the 13th attempt in Dubai.
India have had a stranglehold over their neighbours in World Cup matches, prevailing in each of the dozen previous occasions they had met – seven at 50-over level and five in T20s – but that was broken in jaw-dropping fashion.
After Shaheen Shah Afridi bowled with pace and verve in his three for 31 to restrict India to 151 for seven, Babar and Rizwan took centre stage with an unbroken 152-run stand to wrap up a remarkable 10-wicket win.
This marked the first time Pakistan had won a T20 international by such a margin, with Rizwan contributing an unbeaten 79 off 55 balls and Babar 68 not out from 52 deliveries as they won with 2.1 overs to spare.
A 16,466 crowd, made up mainly of India supporters, had cheered as Virat Kohli marshalled India’s innings with 57 from 49 deliveries, leading the recovery from 31 for three after being invited to bat first on a sluggish pitch.
But they became increasingly subdued as the nerveless pair of Babar and Rizwan whittled down the target to help Pakistan off to a flyer in the Super 12 stage on a hot and sweaty evening under lights in Dubai.
The two countries only play against each other in global tournaments nowadays because of the uneasy relations between the two cricketing boards.
