Gas mains in Grey Street are being urgently replaced during lockdown.
The "critical" works are being carried out from Monday, April 27 and are expected to last around four weeks.
Northern Gas Networks say that they will be " observing strict Government guidelines for safe distance working and following health and safety guidance".
The work involves replacing 150m of gas main which has undergone several emergency repairs in recent years, and has now been prioritised for urgent replacement.
The scheme has been planned in conjunction with Newcastle City Council and will take place in the pedestrian zone near Monument, outside Pret-a-Manger, and at the junction of Grey Street and Mosley Street.
Initial investigation works will be carried out on the junction of Grey Street and Mosley Street to determine whether it will be necessary to introduce temporary traffic lights during the works.
Access will be maintained for motorists and pedestrians should traffic lights be required.
Andrew Rodda, site manager for Northern Gas Networks, said: “We have worked closely with Newcastle City Council to plan this critical work.
"Everything is being done to ensure the safety of our workers and the public during this project, in line with Government and health guidelines.
“We are committed to ensuring the smooth running of the gas network during this challenging time, and to keeping our customers and colleagues safe.”
