A total of 772 more people have tested positive for coronavirus in Ireland, while six further people have died.
The latest announcement was made by Chief Medical Officer Dr Tony Holohan this evening.
Dublin has seen the biggest increase in new cases once again, with 228 further infections, followed by Cork with 120.
While there has been 50 new infections in Meath, 41 in Donegal, 41 in Galway and the remaining 292 cases are spread across all remaining counties.
As of 2pm today 325 Covid-19 patients are hospitalised, of which 42 are in ICU. 15 additional hospitalisations in the past 24 hours.
Of the cases notified today:
- 362 are men / 406 are women
- 64% are under 45 years of age
- The median age is 36 years old
Professor Philip Nolan, Chair of the NPHET Irish Epidemiological Modelling Advisory Group, said: “The reproduction number is now close to 1.0 nationally. This is the first time in a number of weeks that we have been able to report positive indicators of the disease.
"However, our experience to date shows this type of progress is very fragile. We should take these positive signs as an indication our efforts are starting to work, the critical thing now is to keep it up, the virus will seek out any opportunity to spread; over the next weeks let’s make sure we don’t give it that opportunity, by driving R and case numbers as low as possible.”
It comes after it emerged that a coronavirus strain that started in Spain in June has spread across Europe and now makes up a large proportion of infections in several countries, including Ireland.
Researchers have highlighted the role of travel in the pandemic and the need to track mutations.
The variant, which has not been found to be inherently more dangerous, was first identified among farm workers in the eastern Spanish regions of Aragon and Catalonia.
Over the last two months, it has accounted for close to 90% of new infections in Spain, according to the research paper, authored by seven researchers with backing by Swiss and Spanish public-sector science institutions.
It was posted on a so-called preprint server and is yet to be peer reviewed for publication in a scientific journal.
The strain has crossed European borders and accounted for 40-70% of new infections in Switzerland, Ireland and the United Kingdom in September, they found.
The scientists said the strain's characteristic mutation did not give it any apparent edge and its success may be down to the people who caught it first being particularly mobile and sociable.
But in some places outside Spain the variant's journey developed a dynamic of its own, indicating it may have a transmission advantage.
"Its frequency in the UK has continued to increase even after quarantine-free travel was discontinued and the main summer travel period ended. Thus this variant might transmit faster than competing variants," the researchers wrote.
Efforts to sequence viral genomes differ widely across Europe, limiting their research, they said.
"The rapid rise of these variants in Europe highlights the importance of genomic surveillance of the SARS-CoV-2 pandemic…it is imperative to understand whether novel variants impact the severity of the disease."
The World Health Organisation said in July that there was no evidence mutations of the virus had led to more severe disease.
It formed a working group to better understand how mutations behave.
All viruses make only imperfect copies of themselves when they infect a host but the tendency for this random drift varies between classes of viruses.
Coronaviruses, which were also behind the 2002-2004 SARS outbreak, are known to be more stable than, for instance, the seasonal flu, which requires a new vaccine every year.
