Coronavirus’ spread has reached a “decisive point”, the World Health Organisation chief has said, as he urged governments to take “aggressive” action to prevent it. “Every country must be ready for its first case, its first cluster, the first evidence of community transmission and for dealing with sustained community transmission. And it must be preparing for all of those scenarios at the same time,” Tedros Adhanom Ghebreyesus said.
It follows a warning from Australia’s Scott Morrison said that “there is every indication the world will soon enter a pandemic phase”. More than 2,800 people have now been killed by the virus around the globe, and more than 82,000 infected – including Iran’s vice-president Masoumeh Ebtekar.
In Britain, where 15 people have tested positive, the NHS fears that its weakest patients could be denied lifesaving care if the virus overwhelms hospitals. A doctors’ practice and a number of schools have closed over disease fears. Meanwhile, Saudi Arabia has banned foreigners from entering – including religious pilgrims hoping to visit Mecca, Islam’s holiest site – and Japan has logged its first case of a patient who had previously recovered testing positive for a second time.
Mr McBride added: "I don't think it should cause [the public] a lot of concern. I think we should reassure the public as we have been doing all along - as the minister has said repeatedly it wasn't a case of if but when we would have a case in Northern Ireland.
"We have now seen our first case in Northern Ireland - someone returning from northern Italy - and that is not unexpected."
The patient had recently travelled from Italy via Dublin, the country's chief medical officer Michael McBride said.
Mr McBridge said authorities are "working rapidly" to identify anyone the patient came into contact with to prevent a further spread.
The FTSE 100 leading index of UK companies has lost £152bn in value in the past four days, over fears of the coronavirus outbreak.
The index has fallen 8.2 per cent so far this week, shedding £62bn today.
Around 50 Britons at the H10 Costa Adeje Palace Hotel in Tenerife will be able to leave, sources have told the PA news agency.
They are among 168 Britons currently being held on the site after at least four guests were diagnosed with coronavirus.
Three more people have died in Italy from coronavirus, bringing the death toll from the worst outbreak of the illness in Europe to 17, the Civil Protection Agency said.
The number of confirmed cases has risen to 650, officials said, from 528 announced at a news conference some seven hours earlier. The vast majority are in the northern regions of Lombardy and Veneto.
Should holidaymakers cancel their trip to Milan? Should they back out of that two-week package to Tenerife? What about Singapore? Here’s everything you need to know about your rights, from Helen Coffey

Can you cancel your holiday amid coronavirus outbreak?
Your rights, explainedMerlin Entertainments, which owns Alton Towers, Thorpe Park, Legoland and other popular attractions, said it has "restricted" its employees' travel to countries with a high risk of coronavirus and has introduced "enhanced cleaning regimes" on its sites.
Legoland is currently closed for winter and will reopen in mid-March, with Alton Towers and Thorpe Park due to open closer to the end of March.
The prime minister's official spokesman said: "The Foreign Office has been in contact with more than 100 British nationals who are staying in the hotel.
"Of course that is always going to be a balance. We're going to be led by the scientific advice into what works."
Speaking to health professionals at the Nuffield Trust Summit in Windsor, Professor Chris Whitty said: "Occasionally things come along which, no matter how good your strategic aim is, will knock you off course for a while.
"If this becomes a global epidemic then the UK will get it, and if it does not become a global epidemic the UK is perfectly capable of containing and getting rid of individual cases leading to onward transmission."
He went on: "We are not saying we will do them, but we have to look at all of them...
The International Monetary Fund is likely to downgrade its growth forecast as result of the impact the coronavirus will have on global economic growth, a spokesman for the IMF has said.
"Clearly the virus is going to have an impact on growth," IMF spokesman Gerry Rice said.
He said he expected a decision soon on the impact of the coronavirus for the IMF and World Bank spring meetings in April, noting a range of options were under consideration.
A top official in the inner circle of Iran‘s president became the latest senior figure in the country to contract the coronavirus, as the number of deaths spiked to at least 26 with 245 cases confirmed, Borzou Daragahi reports.

'There is nothing to worry about': Opaque regime in Iran insists coronavirus under control as vice-president latest high profile patient
Experts suggest Iran underplaying the extent of the virus and cases could be as high as 18,000Some 130 guests will be allowed to leave the quarantined hotel in Tenerife, Spanish news agency EFE has reported, quoting officials.
It is unclear how many Britons are among the guests.
Public Health England is trying to track down everyone who has come into contact with one of the latest people in the UK to be infected with coronavirus.
"The case is a resident of Derbyshire and became infected whilst in Tenerife. Close contacts will be given health advice about symptoms and emergency contact details to use if they become unwell in the 14 days after contact with the confirmed cases. This tried and tested method will ensure we are able to minimise any risk to them and the wider public.
"We are aware that Burbage Primary School in Buxton has taken the decision to close today.
"My team have spoken to the school, assessed the risk and confirmed that there is currently no information to suggest that there is any increased health risk to any pupils or staff at the school and no public health reason to remain closed at the current time."
Dean Wallace, director of public health for Derbyshire County Council, said: "I'd like to reassure people that the risk to the general public remains low and Derbyshire County Council is working with health colleagues to do everything we can to stop the virus spreading and ensure the people of Derbyshire are protected.
"Good hygiene is the best prevention and there are some simple steps you can take to protect you and your family by washing your hands regularly and thoroughly, and if you cough, cover your mouth and nose with a tissue."
Moscow's city leadership has asked China to respect the measures it is taking to limit the spread of coronavirus.
China's embassy had complained about what it described as the "ubiquitous monitoring" of Chinese nationals on Moscow's public transport network in a formal complaint sent to local authorities and leaked to Russian media.
Now, Moscow's mayor Sergei Sobyanin has defended the measures.
"I ask that you relate with understanding to these necessary measures, which are aimed at preventing coronavirus infections from spreading," he wrote in a response to the embassy, the Interfax news agency reported.
A privately-made coronavirus testing kit could be sent to 93 public health laboratories as soon as tomorrow, once the US Food and Drug Administration has approved it, health secretary Alex Azar has said.
At least 40 labs should already be able to test for the disease using existing, modified kit.
Public Health England has sent an expert to Tenerife where dozens are holed up in a hotel after a coronavirus scare.
Professor Yvonne Doyle, the body's medical director, said: "Public Health England has sent a health protection specialist to Tenerife to work with the Spanish authorities to better understand the public health measures that have been put in place in the hotel.
"This includes understanding spread of the virus within the hotel and how the Spanish authorities are monitoring the situation."
It came as one holidaying Briton said the four-star H10 Costa Adeje Palace had turned into a "petri dish" of germs.
Some guests were ignoring quarantine rules, the person told ITV News.
US politicians are likely to legislate to appropriate funding for the anti-coronavirus effort within two weeks, Mitch McConnell has said.
The senate majority leader said he believed bipartisan negotiations would bear fruit.
"I hope they can work expeditiously so the full Senate would be able to take up the legislation within the next two weeks," the Kentucky Republican said.
Lebanon has confirmed its third case of coronavirus, news agency NNA cited the health ministry as saying.
It involved a man who had travelled from Iran on 24 February.
The previous two cases in Lebanon had been tied to an earlier flight from Iran that arrived last week carrying 150 passengers.
An academy chain has closed three of its schools over the coronavirus scare because it has “some students of Italian origin”.
Schools in Wolverhampton, Buckinghamshire and London run by Khalsa Academies Trust will shut for two days for a “deep clean” as a “precautionary measure”.
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